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KMID : 0363320080290030752
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 3 p.752 ~ p.764
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Effects of Doche-tang on Colonic Mucosal Ulcer Induced by DSS in Mice
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Lee Ju-ah
Kong Kyung-hwan
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Abstract
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Objectives : This study was carried out to investigate the effects of Doche-tang on colonic mucosal ulcer induced by dextran sulfate sodium(DSS).
Method : The group was divided into three. The normal group consisted of mice that were not inflammation-induced. The control group was composed of untreated colitis elicited mice. The sample group was administered Doche-tang after colitis elicitation. The effects on colonic mucosal ulcers were evaluated by the morphological change of colonic mucosa, the anti-oxidant effect, HSP 70, , COX-1, COX-2 and iNOS.
Results : In terms of immunohistochemical findings, the distribution of COX-1 in mice treated with Doche-tang noticeably increased more than that in the control group. The distribution of HSP70, , COX-2, iNOS in mioe treated with Doche-tang decreased more than that in the control group. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by transmission electron microscope.
Conclusion : According to the results, Doche-tang is practicable treatment for colonic mucosal ulcer.
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KEYWORD
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Doche-tang, Colonic mucosal ulcer, COX-1, COX-2, Dextran sulfate sodium
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